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Hieab Adams

Dr. Hieab Adams

About

I have a medical background with thorough experience in multidisciplinary research. In parallel to medical school I took part in two full-time research master programs, one in cell biology and one in clinical epidemiology. For three years I performed experimental research at the department of Cell Biology. Here I determined interaction networks of transcription factors for mental disorders in neural stem cells. On the other hand, I performed observational research at the department of Epidemiology focusing on population genetics and neuroimaging of age-related neurodegenerative diseases. My research was focused on the etiology of such diseases. Here I developed novel statistical methods and neuroimaging protocols, performed image processing, and genome/exome/epigenetic/transcriptome-wide association studies. Furthermore, this research had a very collaborative and international character.

I am the PI of the Precision Epidemiology group, where we characterize large populations in depth using cutting edge imaging and omics technologies. The diverse background of the group members – spanning fundamental research, epidemiology, bioinformatics, and clinical medicine – enables this envisioned multidisciplinary research line. So far I have over 100 publications, with over 80% in the top 25% journals of their respective fields. I have initiated and led multiple global consortia, including the JPND-funded HD-READY and Full-HD consortia, the UNIVRSE consortium, and more recently the UNITED consortium, which is the largest neuroimaging consortium worldwide focusing on neurodegeneration.

    Positions

    • Associate Professor, departments of Clinical Genetics and Radiology, Erasmus MC, Rotterdam, the Netherlands
    • Resident, n.i.t., Department of Clinical Genetics, Erasmus MC, Rotterdam, the Netherlands
    • Senior Editor, Alzheimer’s and Dementia: the journal of the Alzheimer’s Association

    Publications

    • Vilor-Tejedor, N., Evans, T. E., Adams, H. H., González-de-Echávarri, J. M., Molinuevo, J. L., Guigo, R., Gispert, J. D., & Operto, G. (2021). Genetic Influences on Hippocampal Subfields: An Emerging Area of Neuroscience Research. Neurology. Genetics7(3), e591. https://doi.org/10.1212/NXG.0000000000000591
    • Li, S., Weinstein, G., Zare, H., Teumer, A., Völker, U., Friedrich, N., Knol, M. J., Satizabal, C. L., Petyuk, V. A., Adams, H., Launer, L. J., Bennett, D. A., De Jager, P. L., Grabe, H. J., Ikram, M. A., Gudnason, V., Yang, Q., & Seshadri, S. (2020). The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain communications2(2), fcaa176. https://doi.org/10.1093/braincomms/fcaa176
    • Sargurupremraj, M., Suzuki, H., Jian, X., Sarnowski, C., Evans, T. E., Bis, J. C., Eiriksdottir, G., Sakaue, S., Terzikhan, N., Habes, M., Zhao, W., Armstrong, N. J., Hofer, E., Yanek, L. R., Hagenaars, S. P., Kumar, R. B., van den Akker, E. B., McWhirter, R. E., Trompet, S., Mishra, A., Adams, H. H., … Debette, S. (2020). Cerebral small vessel disease genomics and its implications across the lifespan. Nature communications11(1), 6285. https://doi.org/10.1038/s41467-020-19111-2
    • Hofer, E., Roshchupkin, G. V., Adams, H., Knol, M. J., Lin, H., Li, S., Zare, H., Ahmad, S., Armstrong, N. J., Satizabal, C. L., Bernard, M., Bis, J. C., Gillespie, N. A., Luciano, M., Mishra, A., Scholz, M., Teumer, A., Xia, R., Jian, X., Mosley, T. H., … Seshadri, S. (2020). Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nature communications11(1), 4796. https://doi.org/10.1038/s41467-020-18367-y
    • Knol, M. J., Lu, D., Traylor, M., Adams, H., Romero, J., Smith, A. V., Fornage, M., Hofer, E., Liu, J., Hostettler, I. C., Luciano, M., Trompet, S., Giese, A. K., Hilal, S., van den Akker, E. B., Vojinovic, D., Li, S., Sigurdsson, S., van der Lee, S. J., Jack, C. R., Jr, … Alzheimer’s Disease Neuroimaging Initiative (2020). Association of common genetic variants with brain microbleeds: A genome-wide association study. Neurology95(24), e3331–e3343. https://doi.org/10.1212/WNL.0000000000010852

    Click here for all his publications.

    News

    New grant awarded!
    New grant awarded!
    Review on genetic influences on hippocampal subfields published in Neurology Genetics
    Review on genetic influences on hippocampal subfields published in Neurology Genetics
    Hieab Adams wins Erasmus MC Fellowship!
    Hieab Adams wins Erasmus MC Fellowship!
    Cortical regions of interest GWAS published in Nature Communications
    Cortical regions of interest GWAS published in Nature Communications
    Head size and cancer share genetic pathways
    Head size and cancer share genetic pathways
    BDNF gene variants and hippocampal subfields
    BDNF gene variants and hippocampal subfields
    Letter to parliament on science funding
    Letter to parliament on science funding
    Subcortical GWAS published in Nature Genetics
    Subcortical GWAS published in Nature Genetics
    Call for collaborators in the UNITED consortium
    Call for collaborators in the UNITED consortium
    Telorism data processed for 35.000 scans
    Telorism data processed for 35.000 scans
    previous arrow
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    New grant awarded!
    Review on genetic influences on hippocampal subfields published in Neurology Genetics
    Hieab Adams wins Erasmus MC Fellowship!
    Cortical regions of interest GWAS published in Nature Communications
    Head size and cancer share genetic pathways
    BDNF gene variants and hippocampal subfields
    Letter to parliament on science funding
    Subcortical GWAS published in Nature Genetics
    Call for collaborators in the UNITED consortium
    Telorism data processed for 35.000 scans
    previous arrow
    next arrow

    Projects