Hieab Adams

Prof. Dr. Hieab Adams

About

I have a medical background with thorough experience in multidisciplinary research. In parallel to medical school I took part in two full-time research master programs, one in cell biology and one in clinical epidemiology. For three years I performed experimental research at the department of Cell Biology. Here I determined interaction networks of transcription factors for mental disorders in neural stem cells. On the other hand, I performed observational research at the department of Epidemiology focusing on population genetics and neuroimaging of age-related neurodegenerative diseases. My research was focused on the etiology of such diseases. Here I developed novel statistical methods and neuroimaging protocols, performed image processing, and genome/exome/epigenetic/transcriptome-wide association studies. Furthermore, this research had a very collaborative and international character.

I am the PI of the Precision Epidemiology group, where we characterize large populations in depth using cutting edge imaging and omics technologies. The diverse background of the group members – spanning fundamental research, epidemiology, bioinformatics, and clinical medicine – enables this envisioned multidisciplinary research line. So far I have over 100 publications, with over 80% in the top 25% journals of their respective fields. I have initiated and led multiple global consortia, including the JPND-funded HD-READY and Full-HD consortia, the UNIVRSE consortium, and more recently the UNITED consortium, which is the largest neuroimaging consortium worldwide focusing on neurodegeneration.

Positions

Full Professor, Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile
Associate Professor, departments of Clinical Genetics and Radiology, Erasmus MC, Rotterdam, the Netherlands
Resident, n.i.t., Department of Clinical Genetics, Erasmus MC, Rotterdam, the Netherlands
Senior Editor, Alzheimer’s and Dementia: the journal of the Alzheimer’s Association

Publications

Vilor-Tejedor, N., Evans, T. E., Adams, H. H., González-de-Echávarri, J. M., Molinuevo, J. L., Guigo, R., Gispert, J. D., & Operto, G. (2021). Genetic Influences on Hippocampal Subfields: An Emerging Area of Neuroscience Research. Neurology. Genetics, 7(3), e591. https://doi.org/10.1212/NXG.0000000000000591
Li, S., Weinstein, G., Zare, H., Teumer, A., Völker, U., Friedrich, N., Knol, M. J., Satizabal, C. L., Petyuk, V. A., Adams, H., Launer, L. J., Bennett, D. A., De Jager, P. L., Grabe, H. J., Ikram, M. A., Gudnason, V., Yang, Q., & Seshadri, S. (2020). The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain communications, 2(2), fcaa176. https://doi.org/10.1093/braincomms/fcaa176
Sargurupremraj, M., Suzuki, H., Jian, X., Sarnowski, C., Evans, T. E., Bis, J. C., Eiriksdottir, G., Sakaue, S., Terzikhan, N., Habes, M., Zhao, W., Armstrong, N. J., Hofer, E., Yanek, L. R., Hagenaars, S. P., Kumar, R. B., van den Akker, E. B., McWhirter, R. E., Trompet, S., Mishra, A., Adams, H. H., … Debette, S. (2020). Cerebral small vessel disease genomics and its implications across the lifespan. Nature communications, 11(1), 6285. https://doi.org/10.1038/s41467-020-19111-2
Hofer, E., Roshchupkin, G. V., Adams, H., Knol, M. J., Lin, H., Li, S., Zare, H., Ahmad, S., Armstrong, N. J., Satizabal, C. L., Bernard, M., Bis, J. C., Gillespie, N. A., Luciano, M., Mishra, A., Scholz, M., Teumer, A., Xia, R., Jian, X., Mosley, T. H., … Seshadri, S. (2020). Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nature communications, 11(1), 4796. https://doi.org/10.1038/s41467-020-18367-y
Knol, M. J., Lu, D., Traylor, M., Adams, H., Romero, J., Smith, A. V., Fornage, M., Hofer, E., Liu, J., Hostettler, I. C., Luciano, M., Trompet, S., Giese, A. K., Hilal, S., van den Akker, E. B., Vojinovic, D., Li, S., Sigurdsson, S., van der Lee, S. J., Jack, C. R., Jr, … Alzheimer’s Disease Neuroimaging Initiative (2020). Association of common genetic variants with brain microbleeds: A genome-wide association study. Neurology, 95(24), e3331–e3343. https://doi.org/10.1212/WNL.0000000000010852