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Hieab Adams

Dr. Hieab Adams

About

I have a medical background with thorough experience in multidisciplinary research. In parallel to medical school I took part in two full-time research master programs, one in cell biology and one in clinical epidemiology. For three years I performed experimental research at the department of Cell Biology. Here I determined interaction networks of transcription factors for mental disorders in neural stem cells. On the other hand, I performed observational research at the department of Epidemiology focusing on population genetics and neuroimaging of age-related neurodegenerative diseases. My research was focused on the etiology of such diseases. Here I developed novel statistical methods and neuroimaging protocols, performed image processing, and genome/exome/epigenetic/transcriptome-wide association studies. Furthermore, this research had a very collaborative and international character.

I am the PI of the Precision Epidemiology group, where we characterize large populations in depth using cutting edge imaging and omics technologies. The diverse background of the group members – spanning fundamental research, epidemiology, bioinformatics, and clinical medicine – enables this envisioned multidisciplinary research line. So far I have over 100 publications, with over 80% in the top 25% journals of their respective fields. I have initiated and led multiple global consortia, including the JPND-funded HD-READY and Full-HD consortia, the UNIVRSE consortium, and more recently the UNITED consortium, which is the largest neuroimaging consortium worldwide focusing on neurodegeneration.

    Positions

    • Assistant Professor, departments of Clinical Genetics and Radiology, Erasmus MC, Rotterdam, the Netherlands
    • Resident, n.i.t., Department of Clinical Genetics, Erasmus MC, Rotterdam, the Netherlands
    • Senior Editor, Alzheimer’s and Dementia: the journal of the Alzheimer’s Association

    Publications

    1. Li, S, Weinstein, G, Zare, H, Teumer, A, Völker, U, Friedrich, N, Knol, MJ, Satizabal, CL, Petyuk, VA, Adams, HHH, Launer, LJ, Bennett, DA, De Jager, PL, Grabe, HJ, Ikram, MA, Gudnason, V, Yang, Q, Seshadri, S(2020)The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain Commun 2 (2):fcaa176.
    2. Sargurupremraj, M, Suzuki, H, Jian, X, Sarnowski, C, Evans, TE, Bis, JC, Eiriksdottir, G, Sakaue, S, Terzikhan, N, Habes, M, Zhao, W, Armstrong, NJ, Hofer, E, Yanek, LR, Hagenaars, SP, Kumar, RB, van den Akker, EB, McWhirter, RE, Trompet, S, Mishra, A, Saba, Y, Satizabal, CL, Beaudet, G, Petit, L, Tsuchida, A, Zago, L, Schilling, S, Sigurdsson, S, Gottesman, RF, Lewis, CE, Aggarwal, NT, Lopez, OL, Smith, JA, Valdés Hernández, MC, van der Grond, J, Wright, MJ, Knol, MJ, Dörr, M, Thomson, RJ, Bordes, C, Le Grand, Q, Duperron, MG, Smith, AV, Knopman, DS, Schreiner, PJ, Evans, DA, Rotter, JI, Beiser, AS, Maniega, SM, Beekman, M, Trollor, J, Stott, DJ, Vernooij, MW, Wittfeld, K, Niessen, WJ, Soumaré, A, Boerwinkle, E, Sidney, S, Turner, ST, Davies, G, Thalamuthu, A, Völker, U, van Buchem, MA, Bryan, RN, Dupuis, J, Bastin, ME, Ames, D, Teumer, A, Amouyel, P, Kwok, JB, Bülow, R, Deary, IJ, Schofield, PR, Brodaty, H, Jiang, J, Tabara, Y, Setoh, K, Miyamoto, S, Yoshida, K, Nagata, M, Kamatani, Y, Matsuda, F, Psaty, BM, Bennett, DA, De Jager, PL, Mosley, TH, Sachdev, PS, Schmidt, R, Warren, HR, Evangelou, E, Trégouët, DA, International Network against Thrombosis (INVENT) Consortium, International Headache Genomics Consortium (IHGC), Ikram, MA, Wen, W, DeCarli, C, Srikanth, VK, Jukema, JW, Slagboom, EP, Kardia, SLR, Okada, Y, Mazoyer, B, Wardlaw, JM, Nyquist, PA, Mather, KA, Grabe, HJ, Schmidt, H, Van Duijn, CM, Gudnason, V, Longstreth, WT Jr, Launer, LJ, Lathrop, M, Seshadri, S, Tzourio, C, Adams, HH, Matthews, PM, Fornage, M, Debette, S(2020)Cerebral small vessel disease genomics and its implications across the lifespan. Nat Commun 11 (1):6285.
    3. Hofer, E, Roshchupkin, GV, Adams, HHH, Knol, MJ, Lin, H, Li, S, Zare, H, Ahmad, S, Armstrong, NJ, Satizabal, CL, Bernard, M, Bis, JC, Gillespie, NA, Luciano, M, Mishra, A, Scholz, M, Teumer, A, Xia, R, Jian, X, Mosley, TH, Saba, Y, Pirpamer, L, Seiler, S, Becker, JT, Carmichael, O, Rotter, JI, Psaty, BM, Lopez, OL, Amin, N, van der Lee, SJ, Yang, Q, Himali, JJ, Maillard, P, Beiser, AS, DeCarli, C, Karama, S, Lewis, L, Harris, M, Bastin, ME, Deary, IJ, Veronica Witte, A, Beyer, F, Loeffler, M, Mather, KA, Schofield, PR, Thalamuthu, A, Kwok, JB, Wright, MJ, Ames, D, Trollor, J, Jiang, J, Brodaty, H, Wen, W, Vernooij, MW, Hofman, A, Uitterlinden, AG, Niessen, WJ, Wittfeld, K, Bülow, R, Völker, U, Pausova, Z, Bruce Pike, G, Maingault, S, Crivello, F, Tzourio, C, Amouyel, P, Mazoyer, B, Neale, MC, Franz, CE, Lyons, MJ, Panizzon, MS, Andreassen, OA, Dale, AM, Logue, M, Grasby, KL, Jahanshad, N, Painter, JN, Colodro-Conde, L, Bralten, J, Hibar, DP, Lind, PA, Pizzagalli, F, Stein, JL, Thompson, PM, Medland, SE, ENIGMA consortium, Sachdev, PS, Kremen, WS, Wardlaw, JM, Villringer, A, van Duijn, CM, Grabe, HJ, Longstreth, WT Jr, Fornage, M, Paus, T, Debette, S, Ikram, MA, Schmidt, H, Schmidt, R, Seshadri, S(2020)Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nat Commun 11 (1):4796.
    4. Knol, MJ, Lu, D, Traylor, M, Adams, HHH, Romero, JRJ, Smith, AV, Fornage, M, Hofer, E, Liu, J, Hostettler, IC, Luciano, M, Trompet, S, Giese, AK, Hilal, S, van den Akker, EB, Vojinovic, D, Li, S, Sigurdsson, S, van der Lee, SJ, Jack, CR Jr, Wilson, D, Yilmaz, P, Satizabal, CL, Liewald, DCM, van der Grond, J, Chen, C, Saba, Y, van der Lugt, A, Bastin, ME, Windham, BG, Cheng, CY, Pirpamer, L, Kantarci, K, Himali, JJ, Yang, Q, Morris, Z, Beiser, AS, Tozer, DJ, Vernooij, MW, Amin, N, Beekman, M, Koh, JY, Stott, DJ, Houlden, H, Schmidt, R, Gottesman, RF, MacKinnon, AD, DeCarli, C, Gudnason, V, Deary, IJ, van Duijn, CM, Slagboom, PE, Wong, TY, Rost, NS, Jukema, JW, Mosley, TH, Werring, DJ, Schmidt, H, Wardlaw, JM, Ikram, MA, Seshadri, S, Launer, LJ, Markus, HS, Alzheimer's Disease Neuroimaging Initiative(2020)Association of common genetic variants with brain microbleeds: A genome-wide association study. Neurology 95 (24):e3331-e3343.
    5. de Leeuw, FA, Karamujić-Čomić, H, Tijms, BM, Peeters, CFW, Kester, MI, Scheltens, P, Ahmad, S, Vojinovic, D, Adams, HHH, Hankemeier, T, Bos, D, van der Lugt, A, Vernooij, MW, Ikram, MA, Amin, N, Barkhof, F, Teunissen, CE, van Duijn, CM, van der Flier, WM(2021)Circulating metabolites are associated with brain atrophy and white matter hyperintensities. Alzheimers Dement 17 (2):205-214.
    6. Vilor-Tejedor, N, Operto, G, Evans, TE, Falcon, C, Crous-Bou, M, Minguillón, C, Cacciaglia, R, Milà-Alomà, M, Grau-Rivera, O, Suárez-Calvet, M, Garrido-Martín, D, Morán, S, Esteller, M, Adams, HH, Molinuevo, JL, Guigó, R, Gispert, JD, ALFA Study(2020)Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study. Brain Struct Funct 225 (8):2331-2345.
    7. Uleman, JF, Melis, RJF, Quax, R, van der Zee, EA, Thijssen, D, Dresler, M, van de Rest, O, van der Velpen, IF, Adams, HHH, Schmand, B, de Kok, IMCM, de Bresser, J, Richard, E, Verbeek, M, Hoekstra, AG, Rouwette, EAJA, Olde Rikkert, MGM(2020)Mapping the multicausality of Alzheimer's disease through group model building. Geroscience :.
    8. Vilor-Tejedor, N, Ikram, MA, Roshchupkin, G, Vinke, EJ, Vernooij, MW, Adams, HHH(2020)Aging-Dependent Genetic Effects Associated to ADHD Predict Longitudinal Changes of Ventricular Volumes in Adulthood. Front Psychiatry 11 :574.
    9. Armstrong, NJ, Mather, KA, Sargurupremraj, M, Knol, MJ, Malik, R, Satizabal, CL, Yanek, LR, Wen, W, Gudnason, VG, Dueker, ND, Elliott, LT, Hofer, E, Bis, J, Jahanshad, N, Li, S, Logue, MA, Luciano, M, Scholz, M, Smith, AV, Trompet, S, Vojinovic, D, Xia, R, Alfaro-Almagro, F, Ames, D, Amin, N, Amouyel, P, Beiser, AS, Brodaty, H, Deary, IJ, Fennema-Notestine, C, Gampawar, PG, Gottesman, R, Griffanti, L, Jack, CR Jr, Jenkinson, M, Jiang, J, Kral, BG, Kwok, JB, Lampe, L, C M Liewald, D, Maillard, P, Marchini, J, Bastin, ME, Mazoyer, B, Pirpamer, L, Rafael Romero, J, Roshchupkin, GV, Schofield, PR, Schroeter, ML, Stott, DJ, Thalamuthu, A, Trollor, J, Tzourio, C, van der Grond, J, Vernooij, MW, Witte, VA, Wright, MJ, Yang, Q, Morris, Z, Siggurdsson, S, Psaty, B, Villringer, A, Schmidt, H, Haberg, AK, van Duijn, CM, Jukema, JW, Dichgans, M, Sacco, RL, Wright, CB, Kremen, WS, Becker, LC, Thompson, PM, Mosley, TH, Wardlaw, JM, Ikram, MA, Adams, HHH, Seshadri, S, Sachdev, PS, Smith, SM, Launer, L, Longstreth, W, DeCarli, C, Schmidt, R, Fornage, M, Debette, S, Nyquist, PA(2020)Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities. Stroke 51 (7):2111-2121.
    10. Cras, TY, Bos, D, Ikram, MA, Vergouwen, MDI, Dippel, DWJ, Voortman, T, Adams, HHH, Vernooij, MW, Roozenbeek, B(2020)Determinants of the Presence and Size of Intracranial Aneurysms in the General Population: The Rotterdam Study. Stroke 51 (7):2103-2110.
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    News

    Hieab Adams wins Erasmus MC Fellowship!
    Cortical regions of interest GWAS published in Nature Communications
    Head size and cancer share genetic pathways
    BDNF gene variants and hippocampal subfields
    Letter to parliament on science funding
    Subcortical GWAS published in Nature Genetics
    Call for collaborators in the UNITED consortium
    Telorism data processed for 35.000 scans
    Defense of p-values published in Nature
    JPND working group statement published
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