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Maria Knol

Drs. Maria Knol

About

After I obtained my BSc in Medicine I followed a research master in Clinical Epidemiology. I performed my master and PhD research at the department of Epidemiology of the Erasmus MC University Medical Center. Currently, I am following the master in Medicine and finalizing my PhD thesis.

The main focus of my research is on omics data within the field of complex neurological diseases. On one hand, I am working on new omics discoveries, mainly using brain imaging markers. On the other hand, I am using omics discoveries in order to understand the underlying pathophysiology of neurological diseases and related traits. Ultimately, my goal is to translate these omics discoveries to the clinic, e.g. by including them in disease prediction tools.

Positions
  • PhD researcher, department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands
Publications
  1. Knol, MJ, Lu, D, Traylor, M, Adams, HH, Rafael J Romero, J, Smith, AV, Fornage, M, Hofer, E, Liu, J, Hostettler, IC, Luciano, M, Trompet, S, Giese, AK, Hilal, S, van den Akker, EB, Vojinovic, D, Li, S, Sigurdsson, S, van der Lee, SJ, Jack, CR Jr, Wilson, D, Yilmaz, P, Satizabal, CL, Liewald, DCM, van der Grond, J, Chen, C, Saba, Y, van der Lugt, A, Bastin, ME, Windham, BG, Cheng, CY, Pirpamer, L, Kantarci, K, Himali, JJ, Yang, Q, Morris, Z, Beiser, AS, Tozer, DJ, Vernooij, MW, Amin, N, Beekman, M, Koh, JY, Stott, DJ, Houlden, H, Schmidt, R, Gottesman, RF, MacKinnon, AD, DeCarli, C, Gudnason, V, Deary, IJ, van Duijn, CM, Slagboom, PE, Wong, TY, Rost, NS, Jukema, JW, Mosley, TH, Werring, DJ, Schmidt, H, Wardlaw, JM, Ikram, MA, Seshadri, S, Launer, LJ, Markus, HS, Alzheimer’s Disease Neuroimaging Initiative(2020)Association of common genetic variants with brain microbleeds: A Genome-wide Association Study. Neurology :.
  2. van der Willik, KD, Licher, S, Vinke, EJ, Knol, MJ, Darweesh, SKL, N van der Geest, J, Schagen, SB, Ikram, MK, Luik, AI, Ikram, MA(2020)Trajectories of cognitive and motor function between ages 45 and 90 years: a population-based study. J. Gerontol. A Biol. Sci. Med. Sci. :.
  3. Armstrong, NJ, Mather, KA, Sargurupremraj, M, Knol, MJ, Malik, R, Satizabal, CL, Yanek, LR, Wen, W, Gudnason, VG, Dueker, ND, Elliott, LT, Hofer, E, Bis, J, Jahanshad, N, Li, S, Logue, MA, Luciano, M, Scholz, M, Smith, AV, Trompet, S, Vojinovic, D, Xia, R, Alfaro-Almagro, F, Ames, D, Amin, N, Amouyel, P, Beiser, AS, Brodaty, H, Deary, IJ, Fennema-Notestine, C, Gampawar, PG, Gottesman, R, Griffanti, L, Jack, CR Jr, Jenkinson, M, Jiang, J, Kral, BG, Kwok, JB, Lampe, L, C M Liewald, D, Maillard, P, Marchini, J, Bastin, ME, Mazoyer, B, Pirpamer, L, Rafael Romero, J, Roshchupkin, GV, Schofield, PR, Schroeter, ML, Stott, DJ, Thalamuthu, A, Trollor, J, Tzourio, C, van der Grond, J, Vernooij, MW, Witte, VA, Wright, MJ, Yang, Q, Morris, Z, Siggurdsson, S, Psaty, B, Villringer, A, Schmidt, H, Haberg, AK, van Duijn, CM, Jukema, JW, Dichgans, M, Sacco, RL, Wright, CB, Kremen, WS, Becker, LC, Thompson, PM, Mosley, TH, Wardlaw, JM, Ikram, MA, Adams, HHH, Seshadri, S, Sachdev, PS, Smith, SM, Launer, L, Longstreth, W, DeCarli, C, Schmidt, R, Fornage, M, Debette, S, Nyquist, PA(2020)Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities. Stroke 51 (7):2111-2121.
  4. de Mol, CL, Jansen, PR, Muetzel, RL, Knol, MJ, Adams, HH, Jaddoe, VW, Vernooij, MW, Hintzen, RQ, White, TJ, Neuteboom, RF(2020)Polygenic Multiple Sclerosis Risk and Population-Based Childhood Brain Imaging. Ann. Neurol. 87 (5):774-787.
  5. Satizabal, CL, Adams, HHH, Hibar, DP, White, CC, Knol, MJ, Stein, JL, Scholz, M, Sargurupremraj, M, Jahanshad, N, Roshchupkin, GV, Smith, AV, Bis, JC, Jian, X, Luciano, M, Hofer, E, Teumer, A, van der Lee, SJ, Yang, J, Yanek, LR, Lee, TV, Li, S, Hu, Y, Koh, JY, Eicher, JD, Desrivières, S, Arias-Vasquez, A, Chauhan, G, Athanasiu, L, Rentería, ME, Kim, S, Hoehn, D, Armstrong, NJ, Chen, Q, Holmes, AJ, den Braber, A, Kloszewska, I, Andersson, M, Espeseth, T, Grimm, O, Abramovic, L, Alhusaini, S, Milaneschi, Y, Papmeyer, M, Axelsson, T, Ehrlich, S, Roiz-Santiañez, R, Kraemer, B, Håberg, AK, Jones, HJ, Pike, GB, Stein, DJ, Stevens, A, Bralten, J, Vernooij, MW, Harris, TB, Filippi, I, Witte, AV, Guadalupe, T, Wittfeld, K, Mosley, TH, Becker, JT, Doan, NT, Hagenaars, SP, Saba, Y, Cuellar-Partida, G, Amin, N, Hilal, S, Nho, K, Mirza-Schreiber, N, Arfanakis, K, Becker, DM, Ames, D, Goldman, AL, Lee, PH, Boomsma, DI, Lovestone, S, Giddaluru, S, Le Hellard, S, Mattheisen, M, Bohlken, MM, Kasperaviciute, D, Schmaal, L, Lawrie, SM, Agartz, I, Walton, E, Tordesillas-Gutierrez, D, Davies, GE, Shin, J, Ipser, JC, Vinke, LN, Hoogman, M, Jia, T, Burkhardt, R, Klein, M, Crivello, F, Janowitz, D, Carmichael, O, Haukvik, UK, Aribisala, BS, Schmidt, H, Strike, LT, Cheng, CY, Risacher, SL, Pütz, B, Fleischman, DA, Assareh, AA, Mattay, VS, Buckner, RL, Mecocci, P, Dale, AM, Cichon, S, Boks, MP, Matarin, M, Penninx, BWJH, Calhoun, VD, Chakravarty, MM, Marquand, AF, Macare, C, Kharabian Masouleh, S, Oosterlaan, J, Amouyel, P, Hegenscheid, K, Rotter, JI, Schork, AJ, Liewald, DCM, de Zubicaray, GI, Wong, TY, Shen, L, Sämann, PG, Brodaty, H, Roffman, JL, de Geus, EJC, Tsolaki, M, Erk, S, van Eijk, KR, Cavalleri, GL, van der Wee, NJA, McIntosh, AM, Gollub, RL, Bulayeva, KB, Bernard, M, Richards, JS, Himali, JJ, Loeffler, M, Rommelse, N, Hoffmann, W, Westlye, LT, Valdés Hernández, MC, Hansell, NK, van Erp, TGM, Wolf, C, Kwok, JBJ, Vellas, B, Heinz, A, Olde Loohuis, LM, Delanty, N, Ho, BC, Ching, CRK, Shumskaya, E, Singh, B, Hofman, A, van der Meer, D, Homuth, G, Psaty, BM, Bastin, ME, Montgomery, GW, Foroud, TM, Reppermund, S, Hottenga, JJ, Simmons, A, Meyer-Lindenberg, A, Cahn, W, Whelan, CD, van Donkelaar, MMJ, Yang, Q, Hosten, N, Green, RC, Thalamuthu, A, Mohnke, S, Hulshoff Pol, HE, Lin, H, Jack, CR Jr, Schofield, PR, Mühleisen, TW, Maillard, P, Potkin, SG, Wen, W, Fletcher, E, Toga, AW, Gruber, O, Huentelman, M, Davey Smith, G, Launer, LJ, Nyberg, L, Jönsson, EG, Crespo-Facorro, B, Koen, N, Greve, DN, Uitterlinden, AG, Weinberger, DR, Steen, VM, Fedko, IO, Groenewold, NA, Niessen, WJ, Toro, R, Tzourio, C, Longstreth, WT Jr, Ikram, MK, Smoller, JW, van Tol, MJ, Sussmann, JE, Paus, T, Lemaître, H, Schroeter, ML, Mazoyer, B, Andreassen, OA, Holsboer, F, Depondt, C, Veltman, DJ, Turner, JA, Pausova, Z, Schumann, G, van Rooij, D, Djurovic, S, Deary, IJ, McMahon, KL, Müller-Myhsok, B, Brouwer, RM, Soininen, H, Pandolfo, M, Wassink, TH, Cheung, JW, Wolfers, T, Martinot, JL, Zwiers, MP, Nauck, M, Melle, I, Martin, NG, Kanai, R, Westman, E, Kahn, RS, Sisodiya, SM, White, T, Saremi, A, van Bokhoven, H, Brunner, HG, Völzke, H, Wright, MJ, van 't Ent, D, Nöthen, MM, Ophoff, RA, Buitelaar, JK, Fernández, G, Sachdev, PS, Rietschel, M, van Haren, NEM, Fisher, SE, Beiser, AS, Francks, C, Saykin, AJ, Mather, KA, Romanczuk-Seiferth, N, Hartman, CA, DeStefano, AL, Heslenfeld, DJ, Weiner, MW, Walter, H, Hoekstra, PJ, Nyquist, PA, Franke, B, Bennett, DA, Grabe, HJ, Johnson, AD, Chen, C, van Duijn, CM, Lopez, OL, Fornage, M, Wardlaw, JM, Schmidt, R, DeCarli, C, De Jager, PL, Villringer, A, Debette, S, Gudnason, V, Medland, SE, Shulman, JM, Thompson, PM, Seshadri, S, Ikram, MA(2019)Genetic architecture of subcortical brain structures in 38,851 individuals. Nat. Genet. 51 (11):1624-1636.
  6. Wang, J, Knol, MJ, Tiulpin, A, Dubost, F, de Bruijne, M, Vernooij, MW, Adams, HHH, Ikram, MA, Niessen, WJ, Roshchupkin, GV(2019)Gray Matter Age Prediction as a Biomarker for Risk of Dementia. Proc. Natl. Acad. Sci. U.S.A. 116 (42):21213-21218.
  7. Knol, MJ, Loehrer, EA, Wen, KX, Bos, D, Ikram, MK, Vernooij, MW, Adams, HHH, Ikram, MA(2020)Migraine Genetic Variants Influence Cerebral Blood Flow. Headache 60 (1):90-100.
  8. van der Lee, SJ, Knol, MJ, Chauhan, G, Satizabal, CL, Smith, AV, Hofer, E, Bis, JC, Hibar, DP, Hilal, S, van den Akker, EB, Arfanakis, K, Bernard, M, Yanek, LR, Amin, N, Crivello, F, Cheung, JW, Harris, TB, Saba, Y, Lopez, OL, Li, S, van der Grond, J, Yu, L, Paus, T, Roshchupkin, GV, Amouyel, P, Jahanshad, N, Taylor, KD, Yang, Q, Mathias, RA, Boehringer, S, Mazoyer, B, Rice, K, Cheng, CY, Maillard, P, van Heemst, D, Wong, TY, Niessen, WJ, Beiser, AS, Beekman, M, Zhao, W, Nyquist, PA, Chen, C, Launer, LJ, Psaty, BM, Ikram, MK, Vernooij, MW, Schmidt, H, Pausova, Z, Becker, DM, De Jager, PL, Thompson, PM, van Duijn, CM, Bennett, DA, Slagboom, PE, Schmidt, R, Longstreth, WT, Ikram, MA, Seshadri, S, Debette, S, Gudnason, V, Adams, HHH, DeCarli, C(2019)A genome-wide association study identifies genetic loci associated with specific lobar brain volumes. Commun Biol 2 :285.
  9. Parker, N, Vidal-Pineiro, D, French, L, Shin, J, Adams, HHH, Brodaty, H, Cox, SR, Deary, IJ, Fjell, AM, Frenzel, S, Grabe, H, Hosten, N, Ikram, MA, Jiang, J, Knol, MJ, Mazoyer, B, Mishra, A, Sachdev, PS, Salum, G, Satizabal, CL, Schmidt, H, Schmidt, R, Seshadri, S, Schumann, G, Völzke, H, Walhovd, KB, Wen, W, Wittfeld, K, Yang, Q, Debette, S, Pausova, Z, Paus, T(2020)Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan. Cereb. Cortex 30 (2):575-586.
  10. Knol, MJ, Heshmatollah, A, Cremers, LGM, Ikram, MK, Uitterlinden, AG, van Duijn, CM, Niessen, WJ, Vernooij, MW, Ikram, MA, Adams, HHH(2019)Genetic variation underlying cognition and its relation with neurological outcomes and brain imaging. Aging (Albany NY) 11 (5):1440-1456.
Search PubMed
News
Genetic variants for head size share genes and pathways with cancer.
Subcortical GWAS published in Nature Genetics
Maria presents at Cognomics conference
Paper on cognition genes published in Aging
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