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Maria Knol

Drs. Maria Knol

About

After I obtained my BSc in Medicine I followed a research master in Clinical Epidemiology. I performed my master and PhD research at the department of Epidemiology of the Erasmus MC University Medical Center. Currently, I am following the master in Medicine and finalizing my PhD thesis.

The main focus of my research is on omics data within the field of complex neurological diseases. On one hand, I am working on new omics discoveries, mainly using brain imaging markers. On the other hand, I am using omics discoveries in order to understand the underlying pathophysiology of neurological diseases and related traits. Ultimately, my goal is to translate these omics discoveries to the clinic, e.g. by including them in disease prediction tools.

Positions
  • PhD researcher, department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands
Publications
  1. Li, S, Weinstein, G, Zare, H, Teumer, A, Völker, U, Friedrich, N, Knol, MJ, Satizabal, CL, Petyuk, VA, Adams, HHH, Launer, LJ, Bennett, DA, De Jager, PL, Grabe, HJ, Ikram, MA, Gudnason, V, Yang, Q, Seshadri, S(2020)The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain Commun 2 (2):fcaa176.
  2. Sargurupremraj, M, Suzuki, H, Jian, X, Sarnowski, C, Evans, TE, Bis, JC, Eiriksdottir, G, Sakaue, S, Terzikhan, N, Habes, M, Zhao, W, Armstrong, NJ, Hofer, E, Yanek, LR, Hagenaars, SP, Kumar, RB, van den Akker, EB, McWhirter, RE, Trompet, S, Mishra, A, Saba, Y, Satizabal, CL, Beaudet, G, Petit, L, Tsuchida, A, Zago, L, Schilling, S, Sigurdsson, S, Gottesman, RF, Lewis, CE, Aggarwal, NT, Lopez, OL, Smith, JA, Valdés Hernández, MC, van der Grond, J, Wright, MJ, Knol, MJ, Dörr, M, Thomson, RJ, Bordes, C, Le Grand, Q, Duperron, MG, Smith, AV, Knopman, DS, Schreiner, PJ, Evans, DA, Rotter, JI, Beiser, AS, Maniega, SM, Beekman, M, Trollor, J, Stott, DJ, Vernooij, MW, Wittfeld, K, Niessen, WJ, Soumaré, A, Boerwinkle, E, Sidney, S, Turner, ST, Davies, G, Thalamuthu, A, Völker, U, van Buchem, MA, Bryan, RN, Dupuis, J, Bastin, ME, Ames, D, Teumer, A, Amouyel, P, Kwok, JB, Bülow, R, Deary, IJ, Schofield, PR, Brodaty, H, Jiang, J, Tabara, Y, Setoh, K, Miyamoto, S, Yoshida, K, Nagata, M, Kamatani, Y, Matsuda, F, Psaty, BM, Bennett, DA, De Jager, PL, Mosley, TH, Sachdev, PS, Schmidt, R, Warren, HR, Evangelou, E, Trégouët, DA, International Network against Thrombosis (INVENT) Consortium, International Headache Genomics Consortium (IHGC), Ikram, MA, Wen, W, DeCarli, C, Srikanth, VK, Jukema, JW, Slagboom, EP, Kardia, SLR, Okada, Y, Mazoyer, B, Wardlaw, JM, Nyquist, PA, Mather, KA, Grabe, HJ, Schmidt, H, Van Duijn, CM, Gudnason, V, Longstreth, WT Jr, Launer, LJ, Lathrop, M, Seshadri, S, Tzourio, C, Adams, HH, Matthews, PM, Fornage, M, Debette, S(2020)Cerebral small vessel disease genomics and its implications across the lifespan. Nat Commun 11 (1):6285.
  3. Hofer, E, Roshchupkin, GV, Adams, HHH, Knol, MJ, Lin, H, Li, S, Zare, H, Ahmad, S, Armstrong, NJ, Satizabal, CL, Bernard, M, Bis, JC, Gillespie, NA, Luciano, M, Mishra, A, Scholz, M, Teumer, A, Xia, R, Jian, X, Mosley, TH, Saba, Y, Pirpamer, L, Seiler, S, Becker, JT, Carmichael, O, Rotter, JI, Psaty, BM, Lopez, OL, Amin, N, van der Lee, SJ, Yang, Q, Himali, JJ, Maillard, P, Beiser, AS, DeCarli, C, Karama, S, Lewis, L, Harris, M, Bastin, ME, Deary, IJ, Veronica Witte, A, Beyer, F, Loeffler, M, Mather, KA, Schofield, PR, Thalamuthu, A, Kwok, JB, Wright, MJ, Ames, D, Trollor, J, Jiang, J, Brodaty, H, Wen, W, Vernooij, MW, Hofman, A, Uitterlinden, AG, Niessen, WJ, Wittfeld, K, Bülow, R, Völker, U, Pausova, Z, Bruce Pike, G, Maingault, S, Crivello, F, Tzourio, C, Amouyel, P, Mazoyer, B, Neale, MC, Franz, CE, Lyons, MJ, Panizzon, MS, Andreassen, OA, Dale, AM, Logue, M, Grasby, KL, Jahanshad, N, Painter, JN, Colodro-Conde, L, Bralten, J, Hibar, DP, Lind, PA, Pizzagalli, F, Stein, JL, Thompson, PM, Medland, SE, ENIGMA consortium, Sachdev, PS, Kremen, WS, Wardlaw, JM, Villringer, A, van Duijn, CM, Grabe, HJ, Longstreth, WT Jr, Fornage, M, Paus, T, Debette, S, Ikram, MA, Schmidt, H, Schmidt, R, Seshadri, S(2020)Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nat Commun 11 (1):4796.
  4. Knol, MJ, Lu, D, Traylor, M, Adams, HHH, Romero, JRJ, Smith, AV, Fornage, M, Hofer, E, Liu, J, Hostettler, IC, Luciano, M, Trompet, S, Giese, AK, Hilal, S, van den Akker, EB, Vojinovic, D, Li, S, Sigurdsson, S, van der Lee, SJ, Jack, CR Jr, Wilson, D, Yilmaz, P, Satizabal, CL, Liewald, DCM, van der Grond, J, Chen, C, Saba, Y, van der Lugt, A, Bastin, ME, Windham, BG, Cheng, CY, Pirpamer, L, Kantarci, K, Himali, JJ, Yang, Q, Morris, Z, Beiser, AS, Tozer, DJ, Vernooij, MW, Amin, N, Beekman, M, Koh, JY, Stott, DJ, Houlden, H, Schmidt, R, Gottesman, RF, MacKinnon, AD, DeCarli, C, Gudnason, V, Deary, IJ, van Duijn, CM, Slagboom, PE, Wong, TY, Rost, NS, Jukema, JW, Mosley, TH, Werring, DJ, Schmidt, H, Wardlaw, JM, Ikram, MA, Seshadri, S, Launer, LJ, Markus, HS, Alzheimer's Disease Neuroimaging Initiative(2020)Association of common genetic variants with brain microbleeds: A genome-wide association study. Neurology 95 (24):e3331-e3343.
  5. van der Willik, KD, Licher, S, Vinke, EJ, Knol, MJ, Darweesh, SKL, van der Geest, JN, Schagen, SB, Ikram, MK, Luik, AI, Ikram, MA(2021)Trajectories of Cognitive and Motor Function Between Ages 45 and 90 Years: A Population-Based Study. J Gerontol A Biol Sci Med Sci 76 (2):297-306.
  6. Armstrong, NJ, Mather, KA, Sargurupremraj, M, Knol, MJ, Malik, R, Satizabal, CL, Yanek, LR, Wen, W, Gudnason, VG, Dueker, ND, Elliott, LT, Hofer, E, Bis, J, Jahanshad, N, Li, S, Logue, MA, Luciano, M, Scholz, M, Smith, AV, Trompet, S, Vojinovic, D, Xia, R, Alfaro-Almagro, F, Ames, D, Amin, N, Amouyel, P, Beiser, AS, Brodaty, H, Deary, IJ, Fennema-Notestine, C, Gampawar, PG, Gottesman, R, Griffanti, L, Jack, CR Jr, Jenkinson, M, Jiang, J, Kral, BG, Kwok, JB, Lampe, L, C M Liewald, D, Maillard, P, Marchini, J, Bastin, ME, Mazoyer, B, Pirpamer, L, Rafael Romero, J, Roshchupkin, GV, Schofield, PR, Schroeter, ML, Stott, DJ, Thalamuthu, A, Trollor, J, Tzourio, C, van der Grond, J, Vernooij, MW, Witte, VA, Wright, MJ, Yang, Q, Morris, Z, Siggurdsson, S, Psaty, B, Villringer, A, Schmidt, H, Haberg, AK, van Duijn, CM, Jukema, JW, Dichgans, M, Sacco, RL, Wright, CB, Kremen, WS, Becker, LC, Thompson, PM, Mosley, TH, Wardlaw, JM, Ikram, MA, Adams, HHH, Seshadri, S, Sachdev, PS, Smith, SM, Launer, L, Longstreth, W, DeCarli, C, Schmidt, R, Fornage, M, Debette, S, Nyquist, PA(2020)Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities. Stroke 51 (7):2111-2121.
  7. de Mol, CL, Jansen, PR, Muetzel, RL, Knol, MJ, Adams, HH, Jaddoe, VW, Vernooij, MW, Hintzen, RQ, White, TJ, Neuteboom, RF(2020)Polygenic Multiple Sclerosis Risk and Population-Based Childhood Brain Imaging. Ann Neurol 87 (5):774-787.
  8. Satizabal, CL, Adams, HHH, Hibar, DP, White, CC, Knol, MJ, Stein, JL, Scholz, M, Sargurupremraj, M, Jahanshad, N, Roshchupkin, GV, Smith, AV, Bis, JC, Jian, X, Luciano, M, Hofer, E, Teumer, A, van der Lee, SJ, Yang, J, Yanek, LR, Lee, TV, Li, S, Hu, Y, Koh, JY, Eicher, JD, Desrivières, S, Arias-Vasquez, A, Chauhan, G, Athanasiu, L, Rentería, ME, Kim, S, Hoehn, D, Armstrong, NJ, Chen, Q, Holmes, AJ, den Braber, A, Kloszewska, I, Andersson, M, Espeseth, T, Grimm, O, Abramovic, L, Alhusaini, S, Milaneschi, Y, Papmeyer, M, Axelsson, T, Ehrlich, S, Roiz-Santiañez, R, Kraemer, B, Håberg, AK, Jones, HJ, Pike, GB, Stein, DJ, Stevens, A, Bralten, J, Vernooij, MW, Harris, TB, Filippi, I, Witte, AV, Guadalupe, T, Wittfeld, K, Mosley, TH, Becker, JT, Doan, NT, Hagenaars, SP, Saba, Y, Cuellar-Partida, G, Amin, N, Hilal, S, Nho, K, Mirza-Schreiber, N, Arfanakis, K, Becker, DM, Ames, D, Goldman, AL, Lee, PH, Boomsma, DI, Lovestone, S, Giddaluru, S, Le Hellard, S, Mattheisen, M, Bohlken, MM, Kasperaviciute, D, Schmaal, L, Lawrie, SM, Agartz, I, Walton, E, Tordesillas-Gutierrez, D, Davies, GE, Shin, J, Ipser, JC, Vinke, LN, Hoogman, M, Jia, T, Burkhardt, R, Klein, M, Crivello, F, Janowitz, D, Carmichael, O, Haukvik, UK, Aribisala, BS, Schmidt, H, Strike, LT, Cheng, CY, Risacher, SL, Pütz, B, Fleischman, DA, Assareh, AA, Mattay, VS, Buckner, RL, Mecocci, P, Dale, AM, Cichon, S, Boks, MP, Matarin, M, Penninx, BWJH, Calhoun, VD, Chakravarty, MM, Marquand, AF, Macare, C, Kharabian Masouleh, S, Oosterlaan, J, Amouyel, P, Hegenscheid, K, Rotter, JI, Schork, AJ, Liewald, DCM, de Zubicaray, GI, Wong, TY, Shen, L, Sämann, PG, Brodaty, H, Roffman, JL, de Geus, EJC, Tsolaki, M, Erk, S, van Eijk, KR, Cavalleri, GL, van der Wee, NJA, McIntosh, AM, Gollub, RL, Bulayeva, KB, Bernard, M, Richards, JS, Himali, JJ, Loeffler, M, Rommelse, N, Hoffmann, W, Westlye, LT, Valdés Hernández, MC, Hansell, NK, van Erp, TGM, Wolf, C, Kwok, JBJ, Vellas, B, Heinz, A, Olde Loohuis, LM, Delanty, N, Ho, BC, Ching, CRK, Shumskaya, E, Singh, B, Hofman, A, van der Meer, D, Homuth, G, Psaty, BM, Bastin, ME, Montgomery, GW, Foroud, TM, Reppermund, S, Hottenga, JJ, Simmons, A, Meyer-Lindenberg, A, Cahn, W, Whelan, CD, van Donkelaar, MMJ, Yang, Q, Hosten, N, Green, RC, Thalamuthu, A, Mohnke, S, Hulshoff Pol, HE, Lin, H, Jack, CR Jr, Schofield, PR, Mühleisen, TW, Maillard, P, Potkin, SG, Wen, W, Fletcher, E, Toga, AW, Gruber, O, Huentelman, M, Davey Smith, G, Launer, LJ, Nyberg, L, Jönsson, EG, Crespo-Facorro, B, Koen, N, Greve, DN, Uitterlinden, AG, Weinberger, DR, Steen, VM, Fedko, IO, Groenewold, NA, Niessen, WJ, Toro, R, Tzourio, C, Longstreth, WT Jr, Ikram, MK, Smoller, JW, van Tol, MJ, Sussmann, JE, Paus, T, Lemaître, H, Schroeter, ML, Mazoyer, B, Andreassen, OA, Holsboer, F, Depondt, C, Veltman, DJ, Turner, JA, Pausova, Z, Schumann, G, van Rooij, D, Djurovic, S, Deary, IJ, McMahon, KL, Müller-Myhsok, B, Brouwer, RM, Soininen, H, Pandolfo, M, Wassink, TH, Cheung, JW, Wolfers, T, Martinot, JL, Zwiers, MP, Nauck, M, Melle, I, Martin, NG, Kanai, R, Westman, E, Kahn, RS, Sisodiya, SM, White, T, Saremi, A, van Bokhoven, H, Brunner, HG, Völzke, H, Wright, MJ, van 't Ent, D, Nöthen, MM, Ophoff, RA, Buitelaar, JK, Fernández, G, Sachdev, PS, Rietschel, M, van Haren, NEM, Fisher, SE, Beiser, AS, Francks, C, Saykin, AJ, Mather, KA, Romanczuk-Seiferth, N, Hartman, CA, DeStefano, AL, Heslenfeld, DJ, Weiner, MW, Walter, H, Hoekstra, PJ, Nyquist, PA, Franke, B, Bennett, DA, Grabe, HJ, Johnson, AD, Chen, C, van Duijn, CM, Lopez, OL, Fornage, M, Wardlaw, JM, Schmidt, R, DeCarli, C, De Jager, PL, Villringer, A, Debette, S, Gudnason, V, Medland, SE, Shulman, JM, Thompson, PM, Seshadri, S, Ikram, MA(2019)Genetic architecture of subcortical brain structures in 38,851 individuals. Nat Genet 51 (11):1624-1636.
  9. Wang, J, Knol, MJ, Tiulpin, A, Dubost, F, de Bruijne, M, Vernooij, MW, Adams, HHH, Ikram, MA, Niessen, WJ, Roshchupkin, GV(2019)Gray Matter Age Prediction as a Biomarker for Risk of Dementia. Proc Natl Acad Sci U S A 116 (42):21213-21218.
  10. Knol, MJ, Loehrer, EA, Wen, KX, Bos, D, Ikram, MK, Vernooij, MW, Adams, HHH, Ikram, MA(2020)Migraine Genetic Variants Influence Cerebral Blood Flow. Headache 60 (1):90-100.
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News
Cortical regions of interest GWAS published in Nature Communications
Head size and cancer share genetic pathways
Subcortical GWAS published in Nature Genetics
Maria presents at Cognomics conference
Paper on cognition genes published in Aging
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